Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/11168
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dc.contributor.authorRistić, Natašaen_US
dc.contributor.authorNestorović, Natašaen_US
dc.contributor.authorManojlović-Stojanoski, Milicaen_US
dc.contributor.authorTrifunović, Svetlanaen_US
dc.contributor.authorAjdžanović, Vladimiren_US
dc.contributor.authorFilipović, Brankoen_US
dc.contributor.authorPendovski, Lazoen_US
dc.contributor.authorMilošević, Vericaen_US
dc.date.accessioned2021-03-23T06:32:17Z-
dc.date.available2021-03-23T06:32:17Z-
dc.date.issued2019-04-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/11168-
dc.description.abstractDexamethasone (Dx) is often used in obstetric practice to promote fetal lung maturation and to prevent respiratory distress syndrome when the risk of preterm delivery persists. This therapy enables survival of the newborn, but also is associated with deleterious effects on the offspring, such as reproductive disorders. The aim of this study was to determine specifically whether prenatal exposure to Dx disturbs the physiological balance between proliferation and apoptosis of germinative cells (GC) in the ovary of 19- and 21-day-old fetuses and thus induces developmental programming of the female reproductive system. Pregnant Wistar rats (n = 10/group), separated into control (vehicle) and Dx-treated (0.5 mg/kg body mass) groups, received injections on gestational days 16, 17, and 18. Exposure to Dx lowered the volume of the fetal ovary by 30% (P < 0.05) in 21-day-old fetuses, as well as the total number of GC in the ovary by 21% (P < 0.05). When compared to the controls, in Dx-exposed fetuses, the total number of PCNA-positive GC was 27% lower at 19 days and 71% lower at 21 days old (P < 0.05), while total numbers of caspase-3-positive GC were 2.3-fold and 34% higher, respectively (P < 0.05). Our results demonstrate that prenatal exposure to Dx diminished proliferation but increased the rate of germinative cell apoptosis, with consequently reduced total germinative cell number and ovary volume. Impairment of fetal oogenesis and fewer GC in the fetal ovary compromise the oogonial stock and thus may constitute a risk of female fertility.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.titleAdverse effect of dexamethasone on development of the fetal rat ovaryen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/fcp.12415-
dc.identifier.urlhttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ffcp.12415-
dc.identifier.urlhttp://onlinelibrary.wiley.com/wol1/doi/10.1111/fcp.12415/fullpdf-
dc.identifier.volume33-
dc.identifier.issue2-
dc.identifier.fpage199-
dc.identifier.lpage207-
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptFaculty of Veterinary Medicine-
Appears in Collections:Faculty of Veterinary Medicine: Journal Articles
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