Analysis of Prognostic Factors As Predictors of Treatment Free Survival in Patients with Chronic Lymphocytic Leukemia-Single Centre Experience

Abstract

Introduction: Chronic lymphocytic leukemia (CLL) is a heterogeneous clonal lymphoproliferative disease originating from activated B lymphocytes that have experienced antigen. The clinical course is very heterogeneous. Some patients never look for treatment, as opposed to others who live and die with an aggressive illness. This clinical heterogeneity is likely a reflection of molecular and cellular heterogeneity, on the basis of which patients with CLL can be divided into subgroups with different clinical-biological characteristics. Aim of the study: Evaluation of prognostic factors in terms of treatment free survival, prognosis and adequate therapeutic approach in patients with CLL. Material and methods: The study is set as retrospective, it includes 300 patients with CLL diagnosed and treated at the University Clinic of Hematology in the period of 10 years (January 2009 - January 2019). The study was performed at the University Clinic for Hematology, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of North Macedonia. We evaluate several prognostic factors in terms of treatment free survival. All results were processed with the statistical program SPSS18 software program. Results: The multivariate Cox Proportional model of Treatment free survival of CLL patients confirmed ECOG, Rai Stage, and spleen size that influence on treatment free survival.. Concusion: In our study, multivariate analysis of treatment free survival and overall survival showed ECOG performance status 0,1 and 2 as a factor influencing both overall survival and treatment free survival