Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/23494
Title: | CHROMOSOMAL ABNORMALITIES IN PHILADELPHIA CHROMOSOME- NEGATIVE CELLS IN PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH FIRST GENERATION TYROSINE KINASE INHIBITOR- SINGLE CENTER EXPERIENCE | Authors: | Trajkova, Sanja Chevrevska, Lidija Pavkovic, Marica Panovska Stavridis, Irina Dukovski, Dushko Popova-Simjanovska Marija Chadievski, Lazar Stojanovikj, Aleksandar |
Keywords: | Chronic myeloic leukemia Imatinib Philadelphia chromosome clone evlotion |
Issue Date: | 10-May-2013 | Publisher: | Radiance Research Academy | Journal: | International Journal of Current Research and Review | Abstract: | Chronic myelogenous leukemia (CML) is characterized by the presence of a Bcr-Abl fusion protein with deregulated tyrosine kinase activity that is required for maintaining the malignant phenotype. Imatinib as a selective inhibitor of Bcr-Abl induces complete cytogenetic remission in the majority of patients with CML in chronic phase. Targeted therapy of CML with imatinib favors the manifestation of Ph-(negative) clone disorders in some patients. Facts indicate that patients on imatinib should be followed with conventional cytogenetics, even after induction of complete remission. We report a case of a patient with CML, in chronic phase treated with imatinib which induces the most common abnormality trisomy 8. | URI: | http://hdl.handle.net/20.500.12188/23494 |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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CML Sanja.pdf | 319.91 kB | Adobe PDF | View/Open |
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