Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/23494
Title: CHROMOSOMAL ABNORMALITIES IN PHILADELPHIA CHROMOSOME- NEGATIVE CELLS IN PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH FIRST GENERATION TYROSINE KINASE INHIBITOR- SINGLE CENTER EXPERIENCE
Authors: Trajkova, Sanja 
Chevrevska, Lidija 
Pavkovic, Marica 
Panovska Stavridis, Irina 
Dukovski, Dushko
Popova-Simjanovska Marija
Chadievski, Lazar 
Stojanovikj, Aleksandar 
Keywords: Chronic myeloic leukemia
Imatinib
Philadelphia chromosome
clone evlotion
Issue Date: 10-May-2013
Publisher: Radiance Research Academy
Journal: International Journal of Current Research and Review
Abstract: Chronic myelogenous leukemia (CML) is characterized by the presence of a Bcr-Abl fusion protein with deregulated tyrosine kinase activity that is required for maintaining the malignant phenotype. Imatinib as a selective inhibitor of Bcr-Abl induces complete cytogenetic remission in the majority of patients with CML in chronic phase. Targeted therapy of CML with imatinib favors the manifestation of Ph-(negative) clone disorders in some patients. Facts indicate that patients on imatinib should be followed with conventional cytogenetics, even after induction of complete remission. We report a case of a patient with CML, in chronic phase treated with imatinib which induces the most common abnormality trisomy 8.
URI: http://hdl.handle.net/20.500.12188/23494
Appears in Collections:Faculty of Medicine: Journal Articles

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