ASSOCIATION BETWEEN HPV DNA INFECTION AND BACTERIAL VAGINOSIS IN WOMEN WITH SQUAMOUS CELL ABNORMALITIES OF THE UTERINE CERVIX

Abstract

The aim of the study was to demonstrate an association between HPV-DNA infection and bacterial vaginosis in women with squamous intraepithelial lesions and squamous invasive cervical cancer, and to determine the prevalence of HPV-DNA infection and bacterial vaginosis. The material is 128 sexually active women with abnormal cervical cytological findings, ie Pap smear, which shows the presence of squamous intraepithelial lesion or squamous invasive cervical cancer, aged 20 to 59 years. The study did not include: pregnant women, women with previous cervical surgery (conization, carbon dioxide laser vaporization, and total hysterectomy), with previous abnormal cytological and histopathological findings of the cervix, women undergoing menstrual bleeding, the last six weeks have been or are under local or systemic antibiotic or antiviral therapy and women who have had sex for the last two days or have had a vaginal toilet. In women we done: HPV-DNA testing and Nugent score system. HPV-DNA infection was detected in 75.00% (96/128) of patients. Out of a total of 128 patients, bacterial vaginosis was found in 56 (43.75%) patients. Out of a total of 128 patients, 50 (39.06%) patients were found to have bacterial vaginosis and HPV-DNA infection at the same time. Out of a total of 96 HPV-DNA positive patients, bacterial vaginosis was present in 50 (52.08%) patients, and the absence of bacterial vaginosis was noted in 46 (47.92%) of HPV-DNA positive patients. Data analysis showed that there was an association between DNA-HPV infection and bacterial vaginosis (chi-square test = 10.836, p = 0.000995, p˂0.05). Our study showed that there is an association between HPV-DNA infection and bacterial vaginosis in women with squamous cell abnormalities of the uterine cervix.