PREDICTIVE VALUE OF TIME FROM VACCINATION TO DELIVERY AT PERINATAL OUTCOME IN PATIENTS PREVIOUSLY VACCINATED AGAINST COVID-19

Abstract

Introduction: Pregnant women are at higher risk for complications of COVID-19, including hospitalization, intensive care unit (ICU) admission, and death, compared to non-pregnant women. Vaccination during pregnancy is routinely recommended preventing morbidity and mortality in both pregnant women and infants in the same way as for other infectious diseases such as influenza and pertussis. Despite the lack of sufficient research, the World Health Organization, Centers for Disease Control and Prevention (CDC), the American College of Obstetricians and Gynecologists (ACOG) and professional organizations for pregnant, postpartum, and lactating women recommend receiving covid-19 vaccination all women who are eligible to receive the vaccine. Objective: To determine the predictive value of the time from vaccination to delivery to perinatal outcome. Material and method: A cross-sectional study was performed with a prospective and retrospective approach, which included 24 patients vaccinated against COVID-19 and hospitalized at University Clinic for Gynecology and Obstetrics - Skopje for delivery from 01.10.2021 to 01.10.2022. Results: By determining the significance of the contribution for prediction of perinatal outcome, it was established that the interval from the time of vaccination to delivery has a weak influence. Increasing the time from vaccination to delivery, the chance of a favorable perinatal outcome increases by 0.50%,therefore, the impact of time from vaccination to delivery is not significant / 95% C. I: 0.797-1.268 / p>0.05. Conclusion: The results of this study indicate that the time from vaccination to delivery has non significant impact in prediction of perinatal outcome in patients vaccinated against Covid-19.