Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/9807
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dc.contributor.authorJordan Minoven_US
dc.contributor.authorJovanka Karadzinska-Bislimovskaen_US
dc.contributor.authorPetrova, Tatjanaen_US
dc.contributor.authorKristin Vasilevskaen_US
dc.contributor.authorRisteska-Kuc, Snezanaen_US
dc.contributor.authorSaso Stoleskien_US
dc.contributor.authorDragan Mijakoskien_US
dc.date.accessioned2020-12-31T09:45:40Z-
dc.date.available2020-12-31T09:45:40Z-
dc.date.issued2009-06-01-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/9807-
dc.description.abstractObjective. To compare the efficacy and tolerability of different antibiotics empirically administered for exacerbations of chronic bronchitis and chronic obstructive pulmonary disease (COPD). Methods. We performed an observational, non-randomized, open-label study including 226 outpatients with exacerbations of chronic bronchitis and mild or moderate COPD, 123 males and 103 females, aged 24 to 81. All patients were followed up for 30 days, with an intermediate visits at 5 and 10 days at which they were asked about the duration of symptoms (increased expectoration, increased dyspnea and/or presence of purulent sputum) and the side-effects of the drug. Five antibiotic regimens were evaluated: amoxicillin/clavulanic acid 875 mg/125 mg twice daily for 10 days, cefuroxime 250 mg twice daily for 10 days, cefixime 400 mg once daily for 10 days, clarithromycin 500 mg twice daily for 10 days, and ciprofloxacin 500 mg twice daily for 10 days. Results. The clinical success rate, defined as a complete resolution or a return of the symptoms to the baseline severity, in the groups receiving amoxicillin/clavulanic acid, cefuroxime, cefixime, clarithromycin, and ciprofloxacin was 68.9%, 75.0%, 73.5%, 72.7%, and 77.1%, respectively. The mean time to relief of symptoms varied from 6.8 days with amoxicillin/clavulanic acid to 6.1 days with cefuroxime. Relapse within the first month was registered in the group receiving clarithromycin and ciprofloxacin (3.1% and 2.6%, respectively). The prevalence of the adverse events varied from 10.4% with ciprofloxacin, following by 8.9% for amoxicillin/clavulanic acid, 7.5% for cefixime, 6.8% with clarithromycin to 6.1% with cefuroxime. Conclusion. Our findings suggest high efficacy and safety of all studied regimens in the treatment of exacerbations of chronic bronchitis and COPD.en_US
dc.language.isoenen_US
dc.publisherID Design Pressen_US
dc.relation.ispartofMacedonian Journal of Medical Sciencesen_US
dc.subjectAntibioticen_US
dc.subjectchronic bronchitisen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectExacerbationen_US
dc.titleEfficacy and Tolerability of Various Antimicrobial Regimens in the Treatment of Exacerbations of Chronic Bronchitis and Chronic Obstructive Pulmonary Disease in Outpatientsen_US
dc.typeArticleen_US
dc.identifier.urlhttp://versita.metapress.com/index/4GHPV76Q84681532.pdf-
dc.identifier.volume2-
dc.identifier.issue2-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
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