IMMUNOGLOBULIN A NEPHROPATHY IN CHILDHOOD

Abstract

Objectives. Immunoglobulin A nephropathy is a common primary glomerular disease in childhood. The most frequent clinical presentation is hematuria with/or without proteinuria, usually with good prognosis. The characteristics of IgA nephrophaty in Macedonian children are unknown. The aim of the4 sudy eas to describe the caracteristics of immunoglobulin A nephrophaty in children in the Rebulic of Macedonia. Methods. Rhe sudy was performed at yhe Unuversity Pediatric Clinic in Skopje as the only prediatric nephrology center in the country. For the period of 14 years we analyzed 82 childrens at the age of 1-15 years who has diagnosis of glomerular diseases documented by renal biopsy, with soecial attention to immunoglobulin A nephropathy. The data from the history and the renal biopsy findings were analyzed. Results. Immunoglobulin A nephropathy was registred in 14% of cases with primary glomerular disease. The mean age of the patiens was 8.55+_3.53, with predominance of male gander. The most common histopathological finding was focal mesangial proliferation. By immunofluirescency different patterns of IgA deposits were found in 100%.M The most common clinical presentation was recurrent hematuria. Conclusion. Data presented in this study reflect the specifics of immunoglobulin A nephropathy in Macedonian children. Its distribution is similar to that described in other countries with some differences, probably as a result of different selection of patients foe renal biopsy.