2. Repository of UKIM
  3. Faculty of Medicine
  4. Faculty of Medicine: Journal Articles

Repository of UKIM


Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/8099
DC FieldValueLanguage
dc.contributor.authorZanina Pereskaen_US
dc.contributor.authorDaniela Chaparoskaen_US
dc.contributor.authorNiko Bekarovskien_US
dc.contributor.authorIrena Jurukoven_US
dc.contributor.authorNatasha Simonovskaen_US
dc.contributor.authorAleksandra Babulovskaen_US
dc.date.accessioned2020-05-12T07:01:26Z-
dc.date.available2020-05-12T07:01:26Z-
dc.date.issued2019-06-15-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/8099-
dc.description.abstractObjective: Acute organophosphate (OP) poisonings are presented with acetylcholine-receptor overstimulation. There have been a few case reports of thrombotic complications in acute OP poisonings, as well as prolonged thrombosis preconditions in patients who survived this type of intoxications. The paper presents a case with pulmonary thrombosis (PT) that develops in the subacute phase of intentional acute OP poisoning, treated only with atropine, as well as a literature overview of OP-induced prothrombotic toxicity. Case report: A middle aged woman was brought to the hospital after ingestion of unknown insecticide with suicidal intentions. She had a history of HTA (arterial hypertension), hyperlipidemia and untreated depression. The clinical features of poisoning were miosis, vomiting, dizziness, abdominal cramps and diarrhea. Soon after admission, she developed difficulties in breathing with decrease of serum pseudocholinesterase (2590...1769...1644...800 U/l), bibasal pulmonary crackles, drop of SpO2 to 84%. Antidote treatment included carbo medicinalis, atropine, and diazepam, without use of oximes. The seventh day pseudocholinesterase, the levels started to rise but the patient’s hyposaturation (SpO2 86-88%) persisted. Chest ultrasound detected hy￾poechoic subpleural lesion to the right. Haemostatic tests showed increased D-Dimmer (2312 ng/ml) with hy￾percoagulability. The CT pulmonary angiography confirmed PT and after the administration of low molecular heparin, her clinical condition improved. Conclusion: Acute organophosphate poisoning treated with atropine showed a potential for inducing pro￾thrombotic coagulation abnormalities, presented with PT. This life-threatening complication may additionally contribute to prolonged morbidity and mortality in OP poisonings, especially in patients with medical history of comorbidites.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofToxicology Reportsen_US
dc.subjectorganophosphatesen_US
dc.subjectpoisoningen_US
dc.subjectcoagulationen_US
dc.subjectpulmonary thrombosisen_US
dc.subjectatropineen_US
dc.titlePulmonary thrombosis in acute organophosphate poisoning - Case report and literature overview of prothrombotic preconditioning in organophosphate toxicityen_US
dc.typeArticleen_US
dc.identifier.doidoi.org/10.1016/j.toxrep.2019.06.002-
item.fulltextWith Fulltext-
item.grantfulltextopen-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
Files in This Item:
File Description SizeFormat 
Pulmonary_thrombosis_in_acute_organophosphate_pois.pdf843.69 kBAdobe PDFThumbnail
View/Open
Show simple item record

Page view(s)

91
checked on Jul 24, 2024

Download(s)

53
checked on Jul 24, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.