Pulmonary thrombosis in acute organophosphate poisoning - Case report and literature overview of prothrombotic preconditioning in organophosphate toxicity

Zanina Pereska; Daniela Chaparoska; Niko Bekarovski; Irena Jurukov; Natasha Simonovska; Aleksandra Babulovska

Ве молиме користете го овој идентификатор да го цитирате или поврзете овој запис: http://hdl.handle.net/20.500.12188/8099

Наслов:	Pulmonary thrombosis in acute organophosphate poisoning - Case report and literature overview of prothrombotic preconditioning in organophosphate toxicity
Authors:	Zanina Pereska Daniela Chaparoska Niko Bekarovski Irena Jurukov Natasha Simonovska Aleksandra Babulovska
Keywords:	organophosphates poisoning coagulation pulmonary thrombosis atropine
Issue Date:	15-јун-2019
Publisher:	Elsevier
Journal:	Toxicology Reports
Abstract:	Objective: Acute organophosphate (OP) poisonings are presented with acetylcholine-receptor overstimulation. There have been a few case reports of thrombotic complications in acute OP poisonings, as well as prolonged thrombosis preconditions in patients who survived this type of intoxications. The paper presents a case with pulmonary thrombosis (PT) that develops in the subacute phase of intentional acute OP poisoning, treated only with atropine, as well as a literature overview of OP-induced prothrombotic toxicity. Case report: A middle aged woman was brought to the hospital after ingestion of unknown insecticide with suicidal intentions. She had a history of HTA (arterial hypertension), hyperlipidemia and untreated depression. The clinical features of poisoning were miosis, vomiting, dizziness, abdominal cramps and diarrhea. Soon after admission, she developed difficulties in breathing with decrease of serum pseudocholinesterase (2590...1769...1644...800 U/l), bibasal pulmonary crackles, drop of SpO2 to 84%. Antidote treatment included carbo medicinalis, atropine, and diazepam, without use of oximes. The seventh day pseudocholinesterase, the levels started to rise but the patient’s hyposaturation (SpO2 86-88%) persisted. Chest ultrasound detected hypoechoic subpleural lesion to the right. Haemostatic tests showed increased D-Dimmer (2312 ng/ml) with hypercoagulability. The CT pulmonary angiography confirmed PT and after the administration of low molecular heparin, her clinical condition improved. Conclusion: Acute organophosphate poisoning treated with atropine showed a potential for inducing prothrombotic coagulation abnormalities, presented with PT. This life-threatening complication may additionally contribute to prolonged morbidity and mortality in OP poisonings, especially in patients with medical history of comorbidites.
URI:	http://hdl.handle.net/20.500.12188/8099
DOI:	doi.org/10.1016/j.toxrep.2019.06.002
Appears in Collections:	Faculty of Medicine: Journal Articles